Current instructions for Ozempic, Wegovy, Mounjaro, and Zepbound identify the abdomen, thigh, and upper arm as subcutaneous injection areas. Use only the sites and technique in the Instructions for Use (IFU) supplied with your exact presentation, and rotate within the allowed area as its label directs. Compounded products may use a different syringe and must be administered according to the dispensing pharmacy's directions.
These products are labeled for subcutaneous use. The product-specific IFU—not a general rule about angle, pinching, or hold time—is the authority for operating its device.
The Three Approved Injection Sites
The current Wegovy prescribing information and IFUs identify the abdomen, thigh, and upper arm and say to rotate injection sites with each dose. The current Mounjaro prescribing information and IFUs identify the same general areas and direct users to rotate sites. Device designs and instructions vary by product and presentation, so read the IFU packaged with yours.
Abdomen
- Use the abdomen only as described in your product's IFU.
- Do not inject into skin that the IFU tells you to avoid, such as tender, bruised, red, hard, scarred, or damaged areas.
- Choose a different spot within the area for each injection when the IFU directs you to do so.
Thigh
- Follow the illustration and placement directions in your specific IFU; do not infer an exact boundary from a different brand's device guide.
- Choose a different spot for the next injection as directed.
Upper Arm
- Follow your IFU's illustration for upper-arm placement.
- Some product instructions say another person should administer an upper-arm injection; check the directions for your presentation.
If you want a deeper walkthrough of choosing zones within each area, see our dedicated guide to GLP-1 injection sites and rotation.
Needle Angle and Depth Basics
There is no safe universal angle, pinch rule, or hold count for every pen, autoinjector, single-dose syringe, vial-and-syringe product, or compounded product. Follow the written steps and diagrams for the exact device in your hand.
A few practical notes:
- Never share a pen, syringe, or needle, even if the needle has been changed.
- If your device uses a replaceable needle, follow its IFU for attaching, removing, and disposing of each needle.
- If you are unsure whether a full dose was delivered, do not improvise a second dose; follow the product instructions and contact a pharmacist or prescriber.
You may record pain, redness, swelling, or a lump to report to a clinician. A log does not determine whether a reaction is normal or diagnose a skin change.
Rotation Means Following the Exact IFU
The cited labels say to change or rotate injection sites with each dose, but they do not prescribe a universal body-area sequence, custom-zone count, spacing distance, or six-week schedule. Follow the exact text and illustrations for your presentation instead of inventing a calendar.
Some IFUs direct users away from skin that is tender, bruised, red, hard, scarred, damaged, thickened, or lumpy. The wording varies by product. If you notice a persistent lump or other skin change, avoid self-diagnosis and ask a clinician where to inject.
How OffGrid Dose Helps You Rotate
OffGrid Dose maps every logged injection onto a visual body map so you can review where you injected before. The log is a memory aid; it does not medically clear a site or replace the IFU and your clinician's instructions.
The app stores its working data on your device. There is no account, company-operated cloud sync, or server-side health database, so OffGrid Dose does not receive your injection log or health notes. You can see the full feature set on the features page. The app can place a site note beside an injection entry, but it cannot connect a symptom causally to that site. The app supports Ozempic, Wegovy, Mounjaro, Zepbound, compounded semaglutide and tirzepatide, and custom medications.
Frequently Asked Questions
Can I use the same injection site every week?
Follow your product's direction to change injection sites. The reviewed labels do not require rotating among all three body regions or establish a universal one-inch minimum; they do direct users to choose a different spot for each injection.
Does the injection site change how well the medication works?
Manufacturer instructions list the abdomen, thigh, and upper arm as labeled subcutaneous sites without claiming one is superior. Follow the warnings in your product's IFU about skin or locations to avoid.
What angle should I inject a GLP-1 pen?
There is no single angle instruction that applies to every GLP-1 device or compounded syringe. Follow the steps and illustrations in the IFU or dispensing instructions for your exact product.
How do I know if I have lipohypertrophy?
Do not self-diagnose a lump. Avoid the changed area and ask your healthcare provider to assess it and advise where to inject.
How long should I wait before reusing a zone?
The reviewed labels do not give a universal waiting interval for a custom “zone.” They direct users to change the injection site with each injection. Use the exact label and any individualized instruction from your clinician.
This article is for general informational purposes only and is not medical advice. Injection technique, sites, and dosing depend on your specific medication and health situation — always follow your pen's Instructions for Use and consult your healthcare provider or pharmacist before making any changes to how or where you inject.
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